Chemotherapeutics in Cancer

Cancer cells have uncontrolled proliferation because of changes in growth factors, their receptors, intracellular signaling pathways, particularly those controlling the cell cycle and apoptosis, telomerase expression and tumour related angiogenesis. Most anticancer drugs are anti-proliferative. Most damage DNA and initiate apoptosis. They also affect rapidly dividing normal cells and are thus likely to depress bone marrow, impair healing and depress growth. Most cause nausea, vomiting, sterility, hair loss and teratogenicity.

Goals of chemotherapy are for:

• Cure of Cancer
• Control of Cancer
• For Palliation of Symptoms of Cancer

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